With the start of the New Year I often see people contemplate starting to try and live a healthier lifestyle but often don’t because they fear the unknown. People often wonder “What is the right diet for me?” or “how should I be training for maximum progress?” Or “what supplements do I use?” and it all gets so confusing some rather not take any action at all than make a wrong decision.

new year resolution question

Starting any new endeavor is daunting. There is always the possibility of failure. No one wants to fail. Especially if it’s something you are passionate about. I often find that people would rather not try at all, than to try and possibly fail. With the first option it’s easy to say “Oh, I just didn’t try.” In the second option, you have to admit that you did try and weren’t successful.

Here’s the thing – every successful person I have ever met has failed, and usually not just once. Usually, more times then they can count. I can speak from personal experience that I learn more from trying something and not succeeding, then trying something and succeeding. Sometimes, failure is a blessing in a disguise.

Remember that failure is an event, not a person.

Setbacks and failure are inevitable. What makes a champion is how you deal with them. Do you give up or do you keep trying? It is only through failure that you really see how strong you are. Failure is an opportunity to learn more about yourself and what it takes to succeed.

I tell every person who comes to me for coaching to remember that placing dead last is better then not finishing, which is better then did not even trying.

“I can accept failure, everyone fails at something. But I can’t accept not trying.”
Michael Jordan

“Success consists of going from failure to failure without loss of enthusiasm.”
Winston Churchill

As we continue this New Year, please remember to always try your very best, to put everything you have into your diet and training. One day you will wake up, look in the mirror and really like what you see. That day, you will taste success.


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Skinny by Nature – the new hit series present by N2BM

Today, we are going to do is destroy the theory that anyone can get huge by eating right, working out right and using steroid cycles that would make Lee Preist and Ronnie Coleman call you crazy.  The fact of the matter is it takes 3500 calories to gain a pound of muscle, which over the course of a day isn’t really that hard if you’re focused and ready for the huge challenge everyday.

You all have heard the line – “just up your calories but make sure to eat food , as protein shakes are a waste of money.”  Yea the hell with that get your calories in the easiest way you can if you have to use shakes do it.  Bad genes are indeed a real deciding factor sometimes, so your question is what are bad genes?  Well, in short, it’s when no matter how hard you try you will never reach the genetic potential of say a Dennis Wolf because your body simply isn’t designed to reach those results.  You yourself have a small body structure, small wrists, baby ankles and legs with no calves.  Now this doesn’t mean you can’t look great, it just means you are never going to look like a walking refrigerator. Now I can hear the naysayers saying: well I was 109lbs my senior year of high school and now at 21 I’m huge and weight 175lbs.  This means you have half way decent genes, so  consider yourself very lucky.  Men generally stop growing around the ages of 21 to 25, and, chances are, if you’re 25 years old or older and still 110lbs – you might just have bad genes.

While I throw all this negative information at you, I will now provide a light at the end of a dark tunnel.  First off all, the guys out there that say it’s easy just eat more, fix your diet and train are normally guys that aren’t true ectomorphs and have no idea what a real ectomorph is.  As I stated before,  it takes 3500 calories to gain a pound of pure muscle mass.  Thus, lets say you’re a newbie and want to go from 110lbs to a 130lbs; Easy, just eat junk food right?….wrong!  If you’re a hardcore ectomorph you’re going to have to work as hard at eating as you do in the gym to get the results you want.  You wanna get big and muscular not big and fat, so tune in your diet with chicken, milk, a great weight gainer etc., use N2BM Forums to get ideas on diets. Now, I’m going to tell you ectomorphs out there something that will change your life forever, so write this down, put it in your smartphone, get it tattooed on your arm –  but wait a minute! before I tell you put down your drink and sit down I’ll wait……make sure you’re done drinking…….are you done drinking?…..good, now sit down, comfy – good…..ok good here we go.  As an ectomorph your going to have to eat at least 3500 calories a day EVERYDAY pretty much FOREVER or as long you want to keep your muscle mass or until your body slows down, as, normally, ectomorphs have a fast metabolism.

As you put on mass, you’re going to need more calories.  This is going to require dedication and money because food, supplements and protein prices aren’t cheap.  So the next time someone gives you the old tired bulk up lines just tell them everyone is different and genes do play a role when it comes to bodybuilding.  While you won’t look like Arnold,  you can be the best you you can be, and, generally, 20lbs. of muscle over the course 3 to 6 months isn’t too shabby; remember, 20lbs is a hell of a lot of weight.  Trust me, people will notice as you grow and will compliment you, which of course is always nice and those kind of muscle look great on anyone, so remember to enjoy your hard work as well.

Until next time! Stay hungry my friends.


Diet Suggestions for Ectomorphs

  • Anabolic Diet by Dr. Mauro Di Pasquale 
  • BodyOpus by Dan Duchaine
  • CKD Bulker by Lyle McDonald
  • Balanced Gains by Albert Wolf
  • Anabolic TKD Bulking by Albert Wolf



Ketotifen is a second-generation noncompetitive H1antihistamine and mast cell stabilizer with a half life of around 12 hours. Due to its antihistiamine properties, it will bring down regulation of the beta receptors to a halt which we delve into more eventually. It is most commonly sold in as a salt of fumaric acid, ketotifen fumarate, and is available in two different deliveries. We as weekend warriors want to use its oral form, which is used to prevent asthma attacks. Side effects include drowsiness, weight gain, dry mouth, irritability, and increased nosebleeds, appetite, change, diarrhea, chills, increased sweating and insomnia. (http://www.pharma.us.novartis.com/product/pi/pdf/zaditor.pdf)

Ketotifen Inceases LBM

Individuals with wasting syndrome lose muscle aka lean body mass rather than body fat which is due to the lack of anabolic hormones in their body. Several possible alternatives to the approved drugs for AIDS-related wasting are discussed, one of them being Ketotifen. TNF inhibitors prevent inflammation from causing diseases such as Chron’s disease. As a reminder, inflammation is the biggest cause of all diseases. TNF-inhibitors also increase hunger as a decrease inflammation tends to lead in an increase in metabolic rate. This would make perfect sense since an elevated metabolic rate is associated with a healthy immune system. A study combining ketotifen and oxymetholone, the oral anabolic steroid, was presented at the Ninth International AIDS Conference. Preliminary data from a study combining ketotifen and oxymetholone showed that 18 out of 22 patients gained an average of 11.4 pounds after treatment of an average of 3.9 weeks. Sure it was not ketotifen alone, but considering their state of condition, it sure did not counter the effects of oxymetholone.  (Smart T. GMHC Treat Issues. 1995 May;9(5):7-8, 12.)


Ketotifen may prove as another form of HRT

The aim of this study I came across was to identify the sites of the inhibitory action of TNF-alpha (tumor necrosis factor alpha) on LH/hCG injections-stimulated testosterone formation. By using cultured porcine Leydig cells as a model, TNF-alpha was shown to inhibit testosterone secretion when testicular cells were stimulated with hCG but not when incubated with 22R-hydroxycholesterol (a cholesterol substrate derivative that readily passes through cell and mitochondrial membranes). Such an observation suggested that the cytokine may affect cholesterol transport and even the availability to cytochrome P450scc in the mitochondria. Specifically, we report here that TNFalpha reduced in a dose- and time-dependent manner hCG-induced StAR (steroidogenic acute regulatory protein) levels. The maximal and half-maximal effects were obtained with 20 ng/ml and 1.6 ng/ml of TNFalpha, respectively. Maximal inhibitory effects of TNFalpha on StAR messenger RNA and protein levels were obtained after 48 h of treatment. Additionally, the presence of TNFalpha receptors P55 in terms of protein (identified through cross-linking experiments) and messenger RNA (identified through RT-PCR analysis) suggested that the effects of the cytokine are directly exerted on the testicular steroidogenic cell type. So in essence TNF alpha as it rises lowers levels of testosterone. Since, ketotifen is a TNF alpha inhibitor; it may indirectly increase testosterone levels quite substantially; especially if one may be at stake for waste syndrome.  (Mauduit C, et.al Endocrinology 1998 Jun;139(6):2863-8)


I am going to take it one step further and show documentation of a study in which testosterone injections LOWERED levels of TNF alpha in hypogonadal men. Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNFalpha, IL-1beta, and IL-6 and potentiate the expression of the anti inflammatory cytokine IL-10. That is not to say that testosterone does not suppress the Immune system. When testosterone gets to high the body starts to produce less auto immune hormones to make more anabolic hormones. Back to the study; researchers reported a randomized, single-blind, placebo-controlled, crossover study of testosterone replacement in the form of Sustanon 100 vs. placebo in 27 men ranging in age from 53 to 71 years old with low levels of total and free testosterone. When the men were injected with testosterone, levels of TNF alpha and IL-1 beta dropped notably.  Levels of cholesterol had also dropped significantly which shows the heart protective properties of keeping TNF-alpha under control. In conclusion, testosterone replacement shifts the cytokine balance to a state of reduced inflammation and lowers total cholesterol. Twenty of these men had established coronary disease, and because total cholesterol is a cardiovascular risk factor, and pro inflammatory cytokines mediate the development and complications associated with atheromatous plaque, these properties may have particular relevance in men with overt vascular disease. Another reason why a study in the future should be done on Ketotifen and its affects on sex hormones, I predict good things to come from a study of that kind. If you ask me, I will tell you it’s one heck of a drug and should be used in pct, not only because of its positive effects on testosterone but also IGF-1 which we will get into next. (Malkin CJ et.al. J Clin Endocrinol Metab. 2004 Jul;89(7):3313-8.)


In this study, Conscious rats were injected intravenously with recombinant human TNFalpha or vehicle for 24 h. TNFalpha decreased the concentration of both total and free IGF-I in the plasma by 30-40%. This change was associated with a reduction in IGF-I mRNA expression in liver by 39%, gastrocnemius by 73%, soleus by 46% and the heart by 63%, but a 2.5-fold increase in the whole kidney. What I found interesting was that TNFalpha did not alter IGF-II mRNA expression in skeletal muscle. TNFalpha also increased IGFBP-1 in the blood (4times-fold) and this response was associated with an increase in IGFBP-1 mRNA expression in both liver (3times-fold) and kidney (9times-fold). However, IGFBP-3 levels in the blood were reduced 38% in response to the injection of TNFalpha. This change was accompanied by a 60-80% reduction of IGFBP-3 mRNA in the liver and kidney but no significant change in muscle. Hepatic mRNA levels of the acid-labile subunit were also reduced by TNFalpha by 46%. Finally, tissue expression of mac25 (also referred to IGFBP-related protein-1) mRNA was increased in gastrocnemius by 50% but remained unchanged in the liver and kidney. These results more fully characterize the changes in various elements of the IGF system and, thereby, provide potential mechanisms for the alterations in the circulating IGF system as well as for changes in tissue metabolism observed during catabolic insults associated with increased TNFalpha expression. As you see the same applies to IGF-1, the more the TNF alpha the less available IGF one will have. When a TNF inhibitor is presented, IGF levels will rise. (Lang CH et.al Growth Horm IGF Res 2001 Aug;11(4):250-60)

Ketotifen may have anti-catabolic properties

When individuals train hard, TNF alpha has been shown to rise. Of course we know that if you were to take ketotifen post training it would not be as great as prior to training but that is still fine. Caffeine in moderate doses is shown to increase performance yet keep cortisol lower compared to those who train without it. I simply suggesting that taking Ketotifen prior to training like most do will still provide the intended anti-catabolic effects that I theorize about. As I mentioned before, we need more studies done with ketotifen especially regarding its effects on the endocrine system. (Pedersen BK et. al. Exerc Immunol Rev 2001;7:18-31)


Ketotifen aids in easing Irritable Bowel Syndrome

Mast cell activation is thought to be involved in visceral hypersensitivity, one of the main characteristics of the irritable bowel syndrome (IBS). A study was therefore undertaken to investigate the effect of the mast cell stabiliser ketotifen on rectal sensitivity and symptoms in patients with IBS. 60 patients with IBS underwent a barostat study to assess rectal sensitivity before and after 8 weeks of treatment. After the initial barostat, patients were randomized to receive ketotifen or placebo. IBS symptoms and health-related quality of life were scored. In addition, mast cells were quantified and spontaneous release of tryptase and histamine was determined in rectal biopsies and compared with biopsies from 22 age- and gender-matched healthy volunteers. Ketotifen but not placebo increased the threshold for discomfort in patients with IBS with visceral hypersensitivity. This effect was not observed in normosensitive patients with IBS. Ketotifen significantly decreased abdominal pain and other IBS symptoms and improved quality of life. The number of mast cells in rectal biopsies and spontaneous release of tryptase were lower in patients with IBS than in healthy volunteers. Spontaneous release of histamine was mostly undetectable but was slightly increased in patients with IBS compared with healthy volunteers. Histamine and tryptase release were not altered by ketotifen. This study shows that ketotifen increases the threshold for discomfort in patients with IBS with visceral hypersensitivity, reduces IBS symptoms and improves health-related quality of life. Whether this effect is secondary to the mast cell stabilising properties of ketotifen or H(1) receptor antagonism remains to be further investigated. (Gut. 2010 Sep;59(9):1213-21. Epub 2010 Jul 21.)

Combining Ketotifen with other agents

Due to ketotifen’s beta receptor upregulating properties, can be used as aid to one’s clenbuterol cycle. After a week or two on Clen, your beta 2 receptors will be saturated and down regulated. ketitofen will prevent this and even increases fat loss with its upregulating effect on the beta 3 receptors. You can take less of Clen while on ketotifen as well, since ketotifen will increase clen’s effectiveness by a third.

Taking ketotifen with ephedrine is pretty synergistic, as ephedrine works highly upon beta 3 receptors, ketotifen upregulates those beta receptors, thus making it more potent. Plus the fact that it reduces the amount you need for these agents, will in turn reduce the amount of side effects. IF you have the experience and tolerance, stacking all three of these agents would be a tremendous thermogenic fat burning stack.

I recommend taking 1mg of ketotifen 30 minutes prior to a meal twice a day. Remember take it while on clen or ECA to keep the receptors clean and maximize those cycles.


You can post comments about this Article here in this thread —————->>http://www.elitefitness.com/forum/anabolic-steroids/needtogetaas-my-take-ketotifen-980373.html



A phosphodiesterase type 5 inhibitor is a compound that blocks the degradation of phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells lining of the blood vessels; which supplies the corpus cavernosum of the penis with blood flow. PDE-5 Ihibitiors such as Cialis are used in the treatment of erectile dysfunction, and were the first effective oral treatment available for this specific condition. PDE5 is also located in the arterial wall smooth muscle within the lungs, PDE5 inhibitors have also been used for the treatment of pulmonary hypertension, a disease in which blood vessels in the lungs become overflowed with fluid, usually due to the failure of the left ventricle of the heart. PDE5 inhibitors are clinically indicated for the treatment of erectile dysfunction. PDE5 inhibitors are primarily metabolized by the cytochrome P450 enzyme CYP3A4. The potential exists for adverse drug interactions with other drugs which inhibit or induce CYP3A4, including HIV protease inhibitors, ketoconazole, itraconazole, and other anti-hypertensive drugs such as Nitro-spray since it WILL lower blood pressure, which may result in a fatal drop of blood pressure. Taking PDE-5 Inhibitors with grapefruit juice or naringin will also prolong the effect of them, as grapefruit extract inhibits that enzyme from any other action but what is at state. (Adv. Cycl. Nucl. Res. 5:195-211, 1975.) Till this day, Sildenafil Citrate aka Viagra is the most popular PDE5 inhibitor, it was originally discovered during the search of a novel treatment for severe heart spasms. Studies in 2002 explored its potential for increasing the production of neurons after one has suffered as stroke.  (Biochim. Biophys. Acta 284:220-226, 1972.)

A bit about Tadalafil Citrate

Tadalafil Citrate is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction under the name Cialis; and also under the brand name of Adcirca for the treatment of pulmonary arterial hypertension. It initially was developed by the ICOS, and then again refined and marketed world-wide by Lilly ICOS, LLC, the joint partnership company of ICOS Corporation and Eli Lilly & Company. Cialis tablets, in 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40 mg once daily which would have me walking around the house with a hard on all day long for 3 days. LOLOLOL. The US approved Cialis for erectile Dysfunction treatment on November 21, 2003. Recently in May of 2009, Adcirca aka Cialis was passed as an official treatment for pulmonary arterial hypertension. Since it has the ability to stay potent for 3 days, people started to call it the Weekend Pill. For those who don’t get it, basically the dude would take Cialis Friday, and would be screwing from Friday Night to Sunday; to then get ready for the next work week. I personally feel its start to lose its potency after 48 hours from my personal experience. Since it lasts long, dosing is easier than with other PDE-5’s, which also means it acts smoother than the other PDE-5’s as well. I know from experience this holds true, 30 minutes after ingesting Viagra I have to be careful if I go out to public places, as anything could trigger the loyal soldier LOL. With Cialis I do not have that problem; on top of that I never get headaches with Cialis. With Viagra, there are times I have to keep drinking water and not strain so hard, or it will cause me to pass out within the 3 hours of taking it.



Cialis Increase testosterone


Seventy-four consecutive patients were treated on demand with sildenafil 50 mg and tadalafil 20 mg. The success in obtaining sexual intercourse was recorded and total (tT) and free testosterone (fT) levels were studied before and after 3 months of treatment. Basal level of tT and fT were at the bottom of the normal range and LH levels were at the top of the high normal range. After treatments, this endocrine pattern was reversed in both groups. However, the T increase in Sild-treated patients was significantly lower than in those treated with Tad (4·7 ± 2·7 vs. 5·1 ± 0·9, P < 0·001). fT levels followed a directly proportional pattern, while the inverse was found when LH production was studied. The average free testosterone levels increased from 59.9 pmol/L before treatment to 80.4 pmol/L after 3 months of treatment, the authors report. Total testosterone levels also rose (from 11.9 nmol/L to 16.3 nmol/L), while luteinizing hormone (LH) levels declined (from 4.7 IU/L to 2.7 IU/L). The intercourse rate reflected this effect: in fact, the Sild group showed a 4·9 ± 2·9/month full sexual intercourse rate while in the Tad group a significantly higher rate of sexual intercourse was found (6·9 ± 4·6/month, P = 0·04). However, drug consumption was comparable between the groups. (Clin Endocrinol, (Oxf) 2004;61:382–6.)


Researchers had participants perform three 30-second maximum output sprints to exhaustion and measured testosterone and cortisol responses to exercise. They found that only after Cialis and exercise did testosterone increase, however Cialis also increased cortisol levels  which lets us know that you are going to want up your VitaminC intake to combat catabolism. The increase in cortisol also led to lowered levels of DHEA, a drop in DHEA will increase stress and drop immune system capabilities.  The study demonstrates that Cialis increases the “stress” response to the body, just as caffeine does. Caffeine will also temporarily boost testosterone. Caffeine at high doses can cause NON SPECIFIC PDE inhibition. Remember also, an increase in dopamine from the testosterone should result in by product conversion to norepinepherine which would be responsible for the increase in alertness. (Int J Sport Nutr Exerc Metab, 2008 Apr;18(2):131-41.)


Now we come to what separates Cialis from other PDE in inhibitors. In this study, researchers discovered that the increase in testosterone from taking Cialis is mediated by a reduction in estrogen demonstration that Cialis may have anti-estrogenic properties. Research has shown consistently that T/estradiol ratio was associated with LONG TERM Cialis treatment. in LH levels did not rise from Cialis, indicating that Cialis did not directly stimulate testosterone production, but indirectly by lowering estrogen. This could explain why I noticed that I lose water retention while on Cialis, I also get a dry mouth which also is due to the rise Nitric Oxide. I also tend to urinate more often on it, I may have to do some blood work while on Cialis. (Greco EA, Pili M, Bruzziches R, Corona G, Spera G, Aversa A. Testosterone: Estradiol ratio changes associated with long-term tadalafil administration: A pilot study. J Sex Med, 2006;3:716–22.)

Cialis boosts endurance

I came upon a study that involved three maximum power sprints to determine if Cialis could increase anaerobic threshold. The study found no significant differences in peak power, average power or fatigue differences compared to the placebo, but it was noted was that Cialis decreased the time to reach peak power. The researchers concluded, “Cialis did not have an effect on peak power, but time to peak power output was reduced. Only to sports that need to reach maximum power output in a few seconds could Cialis administration be beneficial.”   So those who want faster recovery in between sets will notice a difference while on Cialis, which is probably why guys get so pumped on it. If you are not taking long breaks like before due to the increase endurance, you will notice that you are pushing your limits, causing your muscles to be engorged with blood flow. (Br J Sports Med, 2008 Feb;42(2):130-3.)


Taking Cialis Preworkout seems like a great idea!

Nitric Oxide is one of the main signals for satellite cell activation.  Nitric Oxide is an important regulator of hepatocyte growth factor (HGF), which is a cytokine with various cellular functions on muscle. A research study showed that stretched muscle-induced hypertrophy via release of HGF found that the release of HGF was dependent on NO concentrations. Researchers then measured HGF levels in serum after an intense bout of eccentric exercise. They found that the liver-derived HGF rose 19 percent approximately 4 hours post exercise, which resulted in an activation of satellite cells! It is possible that the observed rise in serum HGF showed that HGF could have been carried to the site of injury by immune cells rushing to the site of injury, which are increased in number during the inflammatory response to muscle damage. As we all know when muscle damage occurs, the overall amount of cytokines present in the body multiplies. The amount of HGF will be much more available while on Cialis, which in essence should increase muscle tissue.   (Mol Biol Cell, 2000;11:1859 –1174.)
Another interesting study reported in the Journal of Muscle and Nerve was that Nitric Oxide actually was able to reverse the damaging effects of cortisol-induced satellite cell depletion. They found that Nitric Oxide had a dose-dependent effect on increasing satellite cell levels as well. If you use the citation you can see the graph, as too much will cause muscle damage and buch of other problems. This brings me to my next point, if you add creatine with Cialis you get a super increase of Satelite cells, this in turn will definitely aid in recovery while improving muscular endurance. A great cocktail conjuction would be N2KTS, 10-20mg of Cialis and 5 grams of creatine monohydrate/ Ancient Strength.  (Muscle Nerve, 2008 Feb;37(2):203-9.)

I just want to remind you guys that when taking Cialis, be sure to start gradual. Start with 5mg, then work your way up by 5mg increments. THERE IS NO NEED TO INGEST MORE THAN 20MG’s within a 3 day period. Other things to take with it to spice up your love life include HCGenerate, iPT 141, Pramipexole, D-aspartic Acid, Unleashed/PostCycle and forma-stanzol.


The one thing that people forget about this drug is the fact that it does NOT stimulate libido. Yes we know that it will increase blood flow to the penis but it no way shape of form stimulates to get it on.  In fact, in order for the penis to work, a hydrogen sulfide signal must be sent from the brain to the penis to allow the nitric oxide flow to begin, on top of that, androgens must be present so that the body can begin the mating process. The body works all in one motion, not in separate terms as you can see. If you stimulate one part, the rest IS affected by it in some way.  I tell you what if you combine something like iPT 141 and Cialis, you will be going for rounds and rounds of sex.